Live, Optical Experimental Neuroimaging Reveals Variations of the Cerebral Blood Flow Response to Ischemic Spreading Depolarization
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Contribution of prostanoid signaling to the evolution of spreading depolarization and the associated cerebral blood flow response
The significance of prostanoid signaling in neurovascular coupling during somatosensory stimulation is increasingly more appreciated, yet its involvement in mediating the cerebral blood flow (CBF) response to spreading depolarization (SD) has remained inconclusive. Selective cyclooxygenase (COX) enzyme inhibitors (NS-398, SC-560) or an antagonist (L161,982) of the EP4 type prostaglandin E2 rece...
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